mouse monoclonal IgG2b; SCF Antibody (G-3) is an IgG2b κ mouse monoclonal SCF antibody (also designated KIT Ligand antibody, Mast Cell Growth Factor antibody, Stem Cell Factor antibody, Familial Progressive Hyperpigmentation 2 antibody, Steel Factor antibody, C-Kit Ligand antibody, Kit Ligand antibody, FPH2 antibody, KL-1 antibody, Kitl antibody, SF antibody, SHEP7 antibody, or KITLG antibody) that detects the SCF protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. SCF Antibody (G-3) is available as both the non-conjugated anti-SCF antibody form, as well as multiple conjugated forms of anti-SCF antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Stem cell factor (SCF) is the ligand for the transmembrane tyrosine kinase receptor proto-oncogene c-Kit. SCF, also designated KL, MGF and SLF, is a pleiotropic cytokine that has two alternatively spliced forms, 248 and 220 amino acids in length in human and mouse systems, respectively. Both the larger form and the smaller form are cleaved to produce soluble forms. The smaller splice variant lacks the proteolytic cleavage site, between amino acids 149 and 177 of the larger SCF form. The larger form of SCF is expressed in fibroblasts, brain and thymus, while the smaller form is found in spleen, testis, placenta and cerebellum. The SCF ligand is essential for the development of germ cells, hematopoietic progenitor cells and melanocyte precursors. SCF can stimulate the proliferation of mature mast cells as well as the maturation and proliferation of immature mast cells.