mouse monoclonal IgG2a; VDR Antibody (D-6) is an IgG2a κ mouse monoclonal VDR antibody (also designated Vitamin D receptor antibody, or NR1I1 antibody) that detects the VDR protein of mouse, rat and human origin by WB, IP, IF and IHC(P). VDR Antibody (D-6) is available as both the non-conjugated anti-VDR antibody form, as well as multiple conjugated forms of anti-VDR antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9-cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma and breast carcinoma cells.