mouse monoclonal IgG1; cathepsin D Antibody (E-7) is an IgG1 κ mouse monoclonal cathepsin D antibody (also designated cathepsin D antibody or CTSD antibody) that detects cathepsin D of human origin by WB, IP, IF, IHC(P), FCM and ELISA. cathepsin D Antibody (E-7) is available as the non-conjugated anti-cathepsin D antibody form, as well as multiple conjugated forms of anti-cathepsin D antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsins may also cleave some protein precursors, thereby releasing regulatory peptides. The promoter region of the cathepsin D gene contains five Sp1 binding sites and four AP-2 binding sites.