mouse monoclonal IgG2b; CASK Antibody (C-6) is an IgG2b κ mouse monoclonal CASK antibody (also designated CASK antibody) that detects the CASK protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. CASK Antibody (C-6) is available as both the non-conjugated anti-CASK antibody form, as well as multiple conjugated forms of anti-CASK antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The MAGUK (membrane-associated guanylate kinase homologs) family of proteins contain multiple protein-binding domains and are involved in cell junction organization, tumor suppression, and signaling. CASK (also designated LIN-2) belongs to a MAGUK subfamily which is characterized by a novel domain structure that consists of a calcium/calmodulin- dependent protein kinase domain followed by PDZ, SH3 and guanylate kinase-like (GUK) domains. CASK is expressed in rat brain where it binds to cell-surface proteins, such as neurexin and syndecan, and is thought to be involved in signaling at neuronal synapses. CASK translocates to the nucleus and interacts with Tbr-1 to form a complex, which binds to a specific DNA sequence (the T-element), and induces the expression of specific genes, including Reelin. CASK displays a transcription regulation function, which appears crucial for cerebrocortical development.