mouse monoclonal IgG2b; DOCK 180 Antibody (H-4) is an IgG2b κ mouse monoclonal DOCK 180 antibody that detects DOCK 180 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. DOCK 180 Antibody (H-4) is available as the non-conjugated anti-DOCK 180 antibody form, as well as multiple conjugated forms of anti-DOCK 180 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The v-Crk oncogene product shares homologous amino acid sequences, designated Src homology region 2 (SH2) and SH3, with many molecules involved in signal transduction. The v-Crk cellular homolog, c-Crk, is a member of a newly emerging class of genes including Nck and GRB2/ASH which encode proteins that consist primarily of SH2 and SH3 domains. Two distinct human c-Crk cDNAs, designated Crk I and Crk II, have been identified and shown to represent alternative splice products of c-Crk. The major translational product of c-Crk I has been identified as a variably expressed protein, while c-Crk II encodes a widely expressed protein and a more variably expressed protein. The major c-Crk transforming activity appears associated with c-Crk I p28 expression. DOCK 180, a protein downstream of Crk, has been identified as a major Crk-associated protein. When DOCK 180 is recruited to the plasma membrane from a cytoplasmic reservoir, presumably by Crk, changes in cellular morphology and spindle formation occur, suggesting DOCK 180 to be a Crk effector molecule.