mouse monoclonal IgG2a; TM Antibody (D-3) is an IgG2a κ mouse monoclonal TM antibody (also designated THBD antibody, TRBM antibody, Fetomodulin antibody, CD141 antibody, THRM antibody, TM antibody, THPH12 antibody, AHUS6 antibody, or BDCA3 antibody) that detects the TM protein of human origin by WB, IP, IF, IHC(P) and FCM. TM Antibody (D-3) is available as both the non-conjugated anti-TM antibody form, as well as multiple conjugated forms of anti-TM antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.