mouse monoclonal IgG1; SREBP-2 Antibody (1C6) is an IgG1 κ mouse monoclonal SREBP-2 antibody (also designated SREBP2 antibody or SREBF2 antibody) that detects the SREBP-2 protein of mouse, rat and human origin by WB, IP and IF. SREBP-2 Antibody (1C6) is available as both the non-conjugated anti-SREBP-2 antibody form, as well as multiple conjugated forms of anti-SREBP-2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a 10 base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SRE-binding proteins (SREBPs) have been identified, including two basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.