mouse monoclonal IgG2a; RACK1 Antibody (B-3) is an IgG2a κ mouse monoclonal RACK1 antibody (also designated HLC-7 antibody, ror GNB2L1 antibody) that detects the RACK1 protein of mouse, rat and human origin by WB, IP, IF and IHC(P). RACK1 Antibody (B-3) is available as both the non-conjugated anti-RACK1 antibody form, as well as multiple conjugated forms of anti-RACK1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function. Receptor for activated C kinases, termed RACKs, are intracellular receptors for activated PKC that may be involved in the activation-induced translocation of PKC. RACK1 (receptor for activated C kinase 1) is a 317 amino acid G protein b subunit-like protein that functions as a RACK and inhibits the activity of Src tyrosine kinases. In response to PKC activation, the intracellular localization of RACK1 and PKC bII changes, and RACK1 and PKC bII co-localize to the same sites. RACK1 is therefore thought to be a shuttling protein for PKC bII. A deficit in RACK1 may be associated with impaired PKC activation in the aging brain. The RACK1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, rice and P.falciparum, and maps to human chromosome 5q35.3.