mouse monoclonal IgG1; Von Hippel Lindau/VHL Antibody (G-7) is an IgG1 κ mouse monoclonal VHL antibody (also designated von Hippel-Lindau tumor suppressor antibody) that detects VHL of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Von Hippel Lindau/VHL Antibody (G-7) is available as the non-conjugated anti-VHL antibody form, as well as multiple conjugated forms of anti-VHL antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Individuals harboring germline mutations in the tumor suppressor gene von Hippel-Lindau (VHL) exhibit an increased susceptibility to a variety of tumors including renal carcinoma, hemangioblastoma of the central nervous system and pheochromocytoma. The Elongin (SIII) complex has been identified as the functional target of the VHL protein. Elongin (SIII) is a heterotrimer composed of a transcriptional active subunit designated Elongin A and two regulatory subunits designated Elongin B and Elongin C. VHL functions by binding to the Elongin B and C subunits, inhibiting the transcriptional efficacy of the Elongin (SIII) complex. Different isoforms of VHL have been observed, encoded by alternatively spliced transcript variants. The molecular weight of each isoform varies between species.