mouse monoclonal IgG2a; Plk Antibody (F-8) is an IgG2a κ mouse monoclonal Plk antibody (also designated PLK1 antibody, PLK-1 antibody, STPK13 antibody or Polo-like kinase 1 antibody) that detects the Plk protein of mouse, rat and human origin by WB, IP, IF and ELISA. Plk Antibody (F-8) is available as both the non-conjugated anti-Plk antibody form, as well as multiple conjugated forms of anti-Plk antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and CDC5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle and both protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation.