mouse monoclonal IgG1; GAP-43 Antibody (B-5) is an IgG1 κ mouse monoclonal GAP-43 antibody (also designated Neuromodulin antibody, or GAP43 antibody) that detects the GAP-43 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. GAP-43 Antibody (B-5) is available as both the non-conjugated anti-GAP-43 antibody form, as well as multiple conjugated forms of anti-GAP-43 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. GAP-43 (growth associated protein 43, B-50, PP46, calmodulin-binding protein P-57, neuromodulin, neuron growth-associated protein 43, protein F1 is a crucial component for regenerative response in the nervous system. It is present at high levels in neuronal growth cones during development and axonal regeneration. GAP-43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. The neuron-specific Elav/Hu family member, HuD, interacts with and stabilizes GAP-43 mRNA in developing neurons and leads to increased levels of GAP-43 protein. Heterozygous GAP-43 knockout mice with GAP-43 levels reduced by one-half dipslay significant memory impairments in cued conditioning or on tests of nociceptive or auditory perception.