mouse monoclonal IgG1; Brg-1 Antibody (G-7) is an IgG1 κ mouse monoclonal Brg-1 antibody (also designated Brg1 antibody, or SMARCA4 antibody) that detects the Brg-1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Brg-1 Antibody (G-7) is available as both the non-conjugated anti-Brg-1 antibody form, as well as multiple conjugated forms of anti-Brg-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2α) and Brg-1 (also designated SNF2β) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).