mouse monoclonal IgG1; Sp2 Antibody (A-8) is an IgG1 κ mouse monoclonal Sp2 antibody (also designated Sp2 antibody) that detects the Sp2 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Sp2 Antibody (A-8) is available as both the non-conjugated anti-Sp2 antibody form, as well as multiple conjugated forms of anti-Sp2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Sp transcription factor family includes Sp1, Sp2, Sp3 (SPR-2) and Sp4 (SPR-1). Sp transcription factors share similar structures but do not share similar functions. All four proteins contain a highly conserved DNA-binding domain composed of three zinc fingers at the C-terminus. Sp family members bind the consensus sequence GGGGCGGGGC and other closely related sequences which are known as GC boxes. Sp1, Sp3 and Sp4 share a high affinity for GC boxes while Sp2 does not. Sp2 only weakly binds to GT boxes. Sp1, Sp2 and Sp3 are ubiquitously expressed, while Sp4 is abundantly expressed in brain with limited expression in other tissues. Sp1 and Sp3, but not Sp2 or Sp4, interact with E2, a regulatory element for the b4 subunit of neuronal nicotinic acetylcholine receptors. Sp3 is the only Sp member to inhibit Sp1 and Sp4 mediated transcription. The gene3 encoding human Sp2 maps to chromosome 17p32.3.