mouse monoclonal IgG1; Annexin VII Antibody (A-1) is an IgG1 κ mouse monoclonal Annexin VII antibody (also designated ANXA7 antibody, Annexin A7 antibody or Synexin antibody) that detects the Annexin VII protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Annexin VII Antibody (A-1) is available as both the non-conjugated anti-Annexin VII antibody form, as well as multiple conjugated forms of anti-Annexin VII antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain, which binds to phospholipids in a Ca++-dependent manner, and a unique amino terminal region, which may confer binding specificity. The annexin family has been implicated as regulators of such diverse processes as ion-flux, endocytosis and exocytosis, and cellular adhesion. When overexpressed in A431 cells, Annexin VI causes a partial reversal of the transformed phenotype. It has been hypothesized that growth-dependent post-translational modifications of Annexins are required for proper sub-cellular localization Annexin VII, also referred to as synexin, is located at the plasma membrane in normal muscle tissue. However, in muscle samples from patients suffering from Duchenne's muscular dystrophy, Annexin VII, along with Annexins IV and VI, are released into the cytoplasm and later, as the disease progresses, into the extracellular space Two forms of Annexin XI, designated A and B, have been identified. Transfection of COS-7 cells with Annexin XI-A, but not Annexin XI-B, causes formation of Annexin XI-associated vesicles.