mouse monoclonal IgG1; CKR-5 Antibody (D-6) is an IgG1 κ mouse monoclonal CKR-5 antibody (also designated CCR5 antibody or CMKBR5 antibody) that detects the CKR-5 protein of mouse, rat and human origin by WB, IP, IF and ELISA. CKR-5 Antibody (D-6) is available as both the non-conjugated anti-CKR-5 antibody form, as well as multiple conjugated forms of anti-CKR-5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. C-C or β chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potent chemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7, CKR-8, CKR-9, CKR-10 and the Duffy blood group antigen. Each of these receptors are G protein-coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation. However, this receptor family has also been shown to facilitate viral infection. Termed a "co-receptor", CKR-5, along with CD4, has been shown to be a major receptor for HIV. CKR-5 tends to associate with macrophage-tropic viruses, such as macrophage tropic HIV-1, while CKR-2B and CKR-3 bind a minority of viruses.