mouse monoclonal IgG1; IQGAP2 Antibody (A-4) is an IgG1 κ mouse monoclonal IQGAP2 antibody that detects the IQGAP2 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. IQGAP2 Antibody (A-4) is available as both the non-conjugated anti-IQGAP2 antibody form, as well as multiple conjugated forms of anti-IQGAP2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. IQGAP1 and IQGAP2 are RasGAP-related Actin binding proteins that interact with the small GTPases Cdc42 and Rac1 and regulate cadherin-mediated cell-cell adhesion. IQGAP1 and IQGAP2 share largely related sequence similarity, and both contain a putative calponin domain, a single WW domain, four conserved IQ or calmodulin-binding domains, and a RasGAP domain. IQGAP1 binds preferentially to the GTP S-bound form of Cdc42, whereas IQGAP2 associates with both nucleotide-bound and nucleotide-free forms of Cdc42. In addition to binding Cdc42, IQGAP1 and IQGAP2 also bind Rac1, F-Actin and calmodulin. The binding of IQGAP proteins to Cdc42 and Rac1 inhibits their intrinsic and RhoGAP-stimulated GTPase activities, which thereby maintains Cdc42 and Rac1 in their active GTP-bound state.