mouse monoclonal IgG1; p47phox Antibody (D-10) is an IgG1 κ mouse monoclonal p47phox antibody (also designated NCF1 antibody, NOXO2 antibody, SH3PXD1A antibody or p47-phox antibody) that detects the p47phox protein of mouse, rat and human origin by WB, IP, IF and ELISA. p47phox Antibody (D-10) is available as both the non-conjugated anti-p47phox antibody form, as well as multiple conjugated forms of anti-p47phox antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47phox and p67-phox. The cytosolic proteins p47phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47phox, suggesting that p47phox may faciliate the transport of p67-phox to the membrane.