mouse monoclonal IgG1; p-RGS9-1 Antibody (A4) is an IgG1 κ mouse monoclonal p-RGS9-1 antibody that detects Ser 475 phosphorylated RGS9-1 of mouse origin by WB. p-RGS9-1 Antibody (A4) is available as the non-conjugated anti-p-RGS9-1 antibody form, as well as multiple conjugated forms of anti-p-RGS9-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Heterotrimeric G proteins function to relay information from cell surface receptors to various intracellular effectors. G proteins comprise a, b and g subunits, and following activation the a subunit binds GTP and dissociates from the bg complex. A large group of proteins have been identified as GTPase-activating proteins (GAPs), including the RGS (regulator of G protein signaling) family, which serve to deactivate specific Ga isoforms by increasing the rate at which they convert GTP to GDP. A subfamily of RGS proteins expressed in the central nervous system contain, in addition to the highly conserved RGS domain, a characteristic GGL domain, or G protein g subunit-like domain, which mediates binding to Gb 5 subunits. This subfamily, which includes RGS6, RGS7, RGS9 and RGS11, associates with Gb 5 to form active GAP complexes that are predominantly localized to the cytosol. RGS/b5 complexes preferentially target Gao subunit for hydrolysis and inhibit Gb1g2-mediated activation of phospholipase C.