Today's drugs are increasingly complex, with most new compounds facing serious solubility and delivery challenges. When traditional approaches fall short, formulators need practical solutions that work across development stages.
Why Hot-Melt Extrusion Matters
Hot-melt extrusion (HME) has emerged as a game-changer in modern drug development—a solvent-free approach that transforms difficult compounds into effective medicines. This guide breaks down the science into clear strategies you can apply to your toughest formulation challenges.
When 90% of new drug candidates struggle with solubility, you need reliable solutions. HME doesn't just address this problem—it solves it by creating stable amorphous solid dispersions that dramatically improve how drugs perform in the body.
Key Benefits Across Development Stages
From early development through commercial production, twin-screw extrusion helps you:
Create consistent drug dispersions at the molecular level for better performance
Significantly boost bioavailability of poorly soluble compounds
Design custom release profiles and innovative dosage forms like films and implants
Move confidently from lab to production with minimal process changes
Beyond Solubility Enhancement
This compendium translates complex variables—like screw configuration, temperature profiles, and processing parameters—into practical knowledge you can apply immediately. It's written for scientists who need solutions that work, whether you're developing:
Oral tablets and capsules
Transdermal patches
Subcutaneous implants
3D-printed dosage forms
Beyond just enhancing solubility, HME opens doors to continuous manufacturing, taste masking, and specialized delivery systems that can set your products apart.
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Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.
