It is the often-ignored simple tips in rodent surgery that make the difference and help minimize postoperative complications and mortality. The presenter will use his years of experience to provide a number of commonsense and simple tips, which will lead to improved surgical outcomes in rodents. The presentation will put emphasis on practical solutions with many visual illustrations to help participants retain the information and apply them to their programs. This presentation is designed for individuals with little, moderate or advanced experience in rodent surgery to help improve surgical and experimental results.