This presentation mainly includes 4 sections, the first one: introduction for CFDA/FDA GLP Regulation and analysis the difference. The second one: introduction of the most important responsibility of veterinarian, for example: to supply support to scientist, to supply veterinary care promptly, to ensure the animal welfare and enrichment. The third one: The procedure for observation of abnormal animal. The fourth one: case for case, for example, alopecia, dehydration, decrease the consumption of food, not drink water, decrease the activity, diarrhea, mass or tumor. Outline - Requirements for animal welfare and veterinary care in related regulations of toxicology study - Requirement for laboratory animals in CFDA GLP regulations - Requirement for laboratory animals in FDA GLP regulations - Requirement for laboratory animals in OECD GLP regulations - Responsibility of veterinarian in the toxicology study - To supply support to scientist - To supply veterinary care promptly - To ensure the animal welfare and enrichment - The procedure for observation of abnormal animal - Case - Alopecia - Dehydration - Decrease the consumption of food, not drink water - Decrease the activity - Diarrhea - Mass or tumor