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Charge heterogeneity in monoclonal antibodies can negatively impact binding affinity and potency, so it is critical to ensure that individual charge variants of biotherapeutic molecules are...
Predicting patient outcomes in cancer treatment is key to creating personalized and effective therapeutic plans. Join Dr. Osman in this engaging webinar as she delves into the cutting-edge w...
Urinary tract infections (UTIs) are among the most prevalent infectious diseases, imposing a significant economic burden on healthcare systems. Traditional microbiological diagnostics for UT...
Antibody–drug conjugates (ADC) are targeted therapies that are designed to deliver highly potent cytotoxic agents to specific tumor cells saving normal tissue. They combined a monoclon...
NGS enables the in-depth analysis of the genome and the identification and investigation of disease-associated variants – especially when workflows include target enrichment, which foc...
Analyzing protein expression in biological samples has traditionally been challenging and often poorly reproducible. While methods like western blot have been around for decades, Simple West...
Join us as we unveil the latest enhancements to our comprehensive suite of workflows designed to transform and streamline the analysis of biotherapeutics. Discover cutting-edge advancements...
Urinalysis is a major diagnostic screening test in the clinical laboratory, with an important role in diagnosing and monitoring nephrological and urological conditions. Until recently, micro...
Identifying and verifying low frequencies of genomic alterations resulting from off-target editing, gRNA synthesis errors, cross-contamination, or other unintended gRNA activity is critical...
The increasing emergence of carbapenem-resistant organisms (CRO), including Enterobacterales (CRE), Pseudomonas aeruginosa (CRPA) and Acinetobacter baumannii (CRAB), is a major public health...
Directing nucleobase deamination or removal can generate precise genomic edits without double-stranded DNA breaks. However, a much broader spectrum of DNA chemical modifications is available...
Gene therapy has experienced an increasing number of successful human clinical trials, leading to 6 FDA approved products using delivery vectors based on adeno-associated viruses (AAV). Thes...
Accurate prediction of CYP2D6 activity from genotype data is of utmost importance as CYP2D6 pharmacogenetic (PGx) testing is increasingly used to guide drug therapy. However, given the compl...
The oral cavity acts as the gateway to the respiratory and digestive tract, and is in continuity with the skin, sharing several of its features and structure. The oral cavity consists of var...
Accurate prediction of CYP2D6 activity from genotype data is of utmost importance as CYP2D6 pharmacogenetic (PGx) testing is increasingly used to guide drug therapy. However, given the compl...
Accurate prediction of CYP2D6 activity from genotype data is of utmost importance as CYP2D6 pharmacogenetic (PGx) testing is increasingly used to guide drug therapy. However, given the compl...
To enhance productivity in research laboratories conducting genomic studies, automation techniques along with rapid workflows are encouraged. Here, we discuss gene expression analysis by rev...
Gene therapy involves introducing a functional gene into the patient's cells to replace a missing or defective one. It has revolutionized the field of medicine and has the potential to c...
T cell lymphocytes play a central role in the adaptive immune response. They are an essential tool of adoptive cell therapy for the treatment of chronic viral infections and malignant diseas...
Cell and gene therapy is at the forefront of medical innovation, offering transformative potential for treating complex diseases. However, achieving success in these therapies requires metic...
The use of biologic-based therapeutics has revolutionized our ability to treat complex diseases such as cancer- and autoimmune-related disorders. Biologic-based therapeutics are known to gen...
In today’s diagnostic test development landscape, the path to commercialization and generating topline revenue is marked by peaks and valleys. One of the first hurdles is navigating th...
Across the entire spectrum of the life sciences sector, from academia and hospitals to pharmaceutical and biotech companies, enormous amounts of resources are invested in the development of...
The path from research discovery to effective immune cell therapies requires innovative approaches to match the challenges we face. Examining the full richness of biological complexity&mdash...
Gene therapy is defined as the treatment of disease by transfer of genetic material into cells, to prevent, treat and potentially even cure a disease. Gene therapies can work by several mech...
Inborn errors of metabolism (IEMs) are rare, devastating disorders caused by pathogenic variants in genes encoding key metabolic enzymes, with the liver playing a critical role in over 140 I...