Stay informed on developments in cancer and oncology diagnosis, prevention and treatment through these curated webinars. As the race toward a cure for cancer continues, advances in cancer research are constantly revealed as innovation in the field of oncology progresses.
Uterine leiomyosarcoma (uLMS) is a rare aggressive sarcoma of the smooth muscle layer of the uterus manifested in high local recurrence and metastatic rate. Currently, effective treatment of...
The microenvironment of many solid tumors impedes many immunotherapeutic treatments by inhibiting the effector functions of many classes of anti-tumor immune cells, including effector T cell...
There are currently several different FDA approved radiopharmaceuticals being used in both large academic and small practice settings to accurately stage and identify local and metastatic pr...
To determine efficacy of specific complementary therapies to advance evidence-based, integrative healthcare, the complementary modality should first be introduced to stakeholders to determin...
Jeff Borgia, Ph.D. is the Director of the Rush Cancer Center Biorepository, where he oversees the collection and annotation of patient specimens in support of ongoing translational research...
Learning Objectives: 1. Explain how obesity impacts the survival of pediatric patients with specific subtypes of leukemia. 2. Describe how obesity impacts T-cell function in pediatric popula...
We started our experience with prostate cancer in 2002 with primitive robotic platforms. Our main goal was to provide an alternative to open and laparoscopic surgery....
Effective cellular therapies for solid tumors remain elusive. Advances in gene editing and synthetic biology offer great potential for improving the safety and functionality of engineered ce...
Immuno-oncology (IO) is a type of cancer treatment that uses the body's immune system to fight cancer. It works by stimulating the immune system to recognize and attack cancer cells, while le...
Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieve a durable complete response. Furthermore,...
Learning Objectives: 1. Classify the obstacles to successful manufacturing of antigen-specific T-cells in immunotherapy. 2. Highlight the effects of CD45RA+ subsets in expansion of antigen-s...
One of the central tenets of biology is that our genetics—our genotype—influences the physical characteristics we manifest—our phenotype. But with more than 25,000 human ge...
The ultimate promise of tumor immunotherapy is dependent on the generation of effective immunity against cancer, including CD4 and CD8 T cell responses. However, activating T cells in cancer...
Every patient is different and so is every tumor! The term “personalized oncology” today is largely associated with sequencing approaches. Current publications proof more and mor...
Immunotherapy has changed the landscape of oncology, improving survival rates for many patients across a variety of malignancies. Two antibody-based immunotherapies, immune checkpoint inhibi...
Brain cancer research stands to benefit from the perspectives, tools, and methodologies of non-traditional fields, such as mechanical engineering. Here, I will discuss our engineering-based...
There are known outcome disparities between Black and White patients with pancreatic neuroendocrine tumors (pNETs). Multiple retrospective series have found that Black patients have more adv...
Breast cancer is the number one cause of cancer in women. Although many risk factors for breast cancer have been identified, only some are modifiable. Since 2004, incidence rates have been r...
Cancer neoantigens arise from protein-altering somatic mutations in tumor and rank among the most promising next-generation immuno-oncology agents when used in combination with immune checkp...
Gene regulatory networks are representations of the relationship between transcription factors and their target genes. By modeling gene regulatory networks, it is possible to identify change...
Mathematical methods can be used to study evolutionary processes associated with carcinogenesis. Selection, mutation, and drift all play a role in cancer dynamics and cancer treatment. I wil...
Precision medicine is transforming cancer care, with next-generation sequencing (NGS) enabling the simultaneous analysis of multiple genomic alterations with therapeutic implications. Howeve...
Adoptive cell therapy (ACT) is an immunotherapy that employs living immune cells to target and destroy cancer cells. However, the inhibitory tumor microenvironment features several obstacles...
In real-world evidence (RWE), temporal shifts in clinical knowledge and practice need to be adjusted for treatment effect assessment. We use electronic health records (EHR) data to 1) assess...
Antibody-based cancer therapies have clear advantages over chemotherapeutic drugs thanks to their high specificity and low risk of side effects. However, it can be difficult to identify targ...
Genomic analysis of cancer cells revealed comprehensive mechanism of tumorigenesis in human patients. Among the abnormalities discovered so far, CNVs accounted for a great portion of all the...
COSMIC is the world’s largest and most comprehensive somatic mutations resource. COSMIC’s contents are manually curated by PhD-level experts from high-quality scientific literatu...
Uterine leiomyosarcoma (uLMS) is a rare aggressive sarcoma of the smooth muscle layer of the uterus manifested in high local recurrence and metastatic rate. Currently, effective treatment of...
