Browse our archive of webinars on pharmaceutical and biomedical research from collaborations between pharmaceutical companies, government, biotechnology companies and academia to create new drug discovery opportunities.
Multiplexing IHC is a technique that is increasing in demand as more and more researchers and physicians are being tasked with doing more with less. With multiplexing, you have the advantage...
Pre-clinical research on cannabis use for arthritis has established clear mechanisms of action, but a few potential problems. While clinical studies are sparse, several surveys of cannabis p...
Marine organisms produce a wide variety of primary and secondary metabolites with unique scaffolds that are biologically active. Manzamines are marine-derived polycyclic alkaloids. Approxima...
Novel immunotherapy has revolutionized the landscape of cancer therapy in multiple tumor types since Ipilimumab, the first ICB agent, was approved for the treatment of metastatic melanoma is...
Short oligonucleotides are an emerging platform for the development of biopharmaceuticals to treat various diseases, including those that are inaccessible to small molecule- and protein-base...
This presentation explores the pharmacokinetics (PK) and pharmacodynamics (PD) of β-lactam antibiotic dosing, particularly in ICU patients. To optimize PK/PD targets, two strategies are...
Surface plasmon resonance is a real-time and label-free technique that offers low sample consumption and high throughput when compared to other biophysical techniques and has been widely ado...
De novo gene synthesis and protein expression are established technologies that can give access to nearly any target DNA or protein sequence, allowing for engineering of biologics. In this p...
Pharmacogenomics has emerged as an early use case of precision medicine. Delivering this new clinical data to clinicians in a ready to use format can be challenging. This talk wil...
Central Nervous System (CNS) therapies have significantly progressed in the last decade, propelled by emerging treatment modalities including gene therapies. Neurological indications remain...
Nucleic acid analysis is crucial for the diagnostics of infectious diseases such as COVID-19. CRISPR/Cas technology, beyond its broad application in gene editing, features, in this regard, a...
Learning Objectives: 1. Describe and discuss some of the unique aspect of in vivo studies. 2. Identify specific study practices to ensure high quality study data and animal welfare. 3. Discu...
Advances in tissue-based technologies over the past few years have created opportunities to identify patterns that can be used as biomarkers and prognostic indicators for different disease s...
In this project, we optimized a high-throughput fluorescent-based assay to assess transporter activity by measuring uptake of the substrate, ASP+ 4-(4-(dimethylamino)styryl)-N-methylpyridi...
Ninety percent of therapeutic agents reaching clinical trial fail to reach entry to market, with safety concerns being a major cause for failures in phase I and II clinical trials. Drug-indu...
Traditional liver perfusion procedures – used to isolate hepatocytes – are difficult to perform and require extensive training, steady hands and long-standing experience. In this...
G Protein Coupled Receptors (GPCRs) are therapeutic targets for many medications used to treat a variety of disease states. A large number of genetic variants have been identified in the gen...
Interoceptive signals dynamically interact with the environment to shape appropriate defensive behaviors. Neurons in the hypothalamus regulate internal states, such as thirst and circadian r...
Background and aim: G protein-coupled receptors (GPCRs) are vital membrane proteins involved in cellular and physiological processes, including sensory perception, signaling, neurotransmissi...
How can labs increase their sample throughput and pipetting accuracy and reproducibility without investing in an expensive automated liquid handler? Electronic pipettes are a cost-effective...
Globally there has been a constant rise in the population suffering from cardiovascular diseases mostly due to metabolic complications. We have made use of two high throughput omics-based ap...
Current cancer research is hindered by the limitations of existing experimental systems, which fall short in demonstrating concordance with human studies. In this way, we aim to develop mode...
DBS for obsessive-compulsive disorder (OCD) achieves clinical benefit in 66% of treatment-resistant patients. However, there is still a lack of a fundamental understanding of the neurophysio...
Recent advances in gene editing has allowed the generation of advanced rodent research models, mimicking some aspects of human conditions. For neurodegenerative disorders such as Alzheimer&r...
Learning Objectives: 1. Summarize the benefits and challenges of current preclinical methods in drug discovery and development. 2. Review new alternative methodologies (NAMs) and microphysio...
Across many cancers, mortality is associated with metastasis and acquired drug resistance, both of which often manifest in recurrent disease. Central to these phenomena is epithelial to mese...
Diosgenin is a botanical steroidal saponin with anti-inflammatory, antioxidant, anti-thrombotic, anti- apoptotic, anti-depressant, and anti-nociceptive properties. However, it's unknown...
Multiplexing IHC is a technique that is increasing in demand as more and more researchers and physicians are being tasked with doing more with less. With multiplexing, you have the advantage...
