Browse our archive of webinars on pharmaceutical and biomedical research from collaborations between pharmaceutical companies, government, biotechnology companies and academia to create new drug discovery opportunities.
Many current technologies used in drug discovery and preclinical development programmes typically involve multi-step operations, extensive hands-on time, and lengthy liquid handling processe...
Pre-clinical research on cannabis use for arthritis has established clear mechanisms of action, but a few potential problems. While clinical studies are sparse, several surveys of cannabis p...
Short oligonucleotides are an emerging platform for the development of biopharmaceuticals to treat various diseases, including those that are inaccessible to small molecule- and protein-base...
Pharmacogenomics has emerged as an early use case of precision medicine. Delivering this new clinical data to clinicians in a ready to use format can be challenging. This talk wil...
Learning Objectives: 1. Describe and discuss some of the unique aspect of in vivo studies. 2. Identify specific study practices to ensure high quality study data and animal welfare. 3. Discu...
This presentation explores the pharmacokinetics (PK) and pharmacodynamics (PD) of β-lactam antibiotic dosing, particularly in ICU patients. To optimize PK/PD targets, two strategies are...
Marine organisms produce a wide variety of primary and secondary metabolites with unique scaffolds that are biologically active. Manzamines are marine-derived polycyclic alkaloids. Approxima...
Nucleic acid analysis is crucial for the diagnostics of infectious diseases such as COVID-19. CRISPR/Cas technology, beyond its broad application in gene editing, features, in this regard, a...
Advances in tissue-based technologies over the past few years have created opportunities to identify patterns that can be used as biomarkers and prognostic indicators for different disease s...
De novo gene synthesis and protein expression are established technologies that can give access to nearly any target DNA or protein sequence, allowing for engineering of biologics. In this p...
Novel immunotherapy has revolutionized the landscape of cancer therapy in multiple tumor types since Ipilimumab, the first ICB agent, was approved for the treatment of metastatic melanoma is...
Ninety percent of therapeutic agents reaching clinical trial fail to reach entry to market, with safety concerns being a major cause for failures in phase I and II clinical trials. Drug-indu...
Central Nervous System (CNS) therapies have significantly progressed in the last decade, propelled by emerging treatment modalities including gene therapies. Neurological indications remain...
G Protein Coupled Receptors (GPCRs) are therapeutic targets for many medications used to treat a variety of disease states. A large number of genetic variants have been identified in the gen...
Traditional liver perfusion procedures – used to isolate hepatocytes – are difficult to perform and require extensive training, steady hands and long-standing experience. In this...
In this project, we optimized a high-throughput fluorescent-based assay to assess transporter activity by measuring uptake of the substrate, ASP+ ï€ 4-(4-(dimethylamino)styryl)-N-methylpyridi...
Surface plasmon resonance is a real-time and label-free technique that offers low sample consumption and high throughput when compared to other biophysical techniques and has been widely ado...
How can labs increase their sample throughput and pipetting accuracy and reproducibility without investing in an expensive automated liquid handler? Electronic pipettes are a cost-effective...
Background and aim: G protein-coupled receptors (GPCRs) are vital membrane proteins involved in cellular and physiological processes, including sensory perception, signaling, neurotransmissi...
Globally there has been a constant rise in the population suffering from cardiovascular diseases mostly due to metabolic complications. We have made use of two high throughput omics-based ap...
Current cancer research is hindered by the limitations of existing experimental systems, which fall short in demonstrating concordance with human studies. In this way, we aim to develop mode...
Interoceptive signals dynamically interact with the environment to shape appropriate defensive behaviors. Neurons in the hypothalamus regulate internal states, such as thirst and circadian r...
DBS for obsessive-compulsive disorder (OCD) achieves clinical benefit in 66% of treatment-resistant patients. However, there is still a lack of a fundamental understanding of the neurophysio...
Recent advances in gene editing has allowed the generation of advanced rodent research models, mimicking some aspects of human conditions. For neurodegenerative disorders such as Alzheimer&r...
Diosgenin is a botanical steroidal saponin with anti-inflammatory, antioxidant, anti-thrombotic, anti- apoptotic, anti-depressant, and anti-nociceptive properties. However, it's unknown...
Our ability to record large-scale neural and behavioral data has substantially improved in the last decade. However, the inference of quantitative dynamical models for cognition and motor co...
NAFLD (non-alcoholic fatty liver disease) is a global epidemic that affects 25% of the world’s population, with its epicentre in the West. Twenty percent of NAFLD patients go on to dev...
Many current technologies used in drug discovery and preclinical development programmes typically involve multi-step operations, extensive hands-on time, and lengthy liquid handling processe...
