MAY 26, 2025 8:57 AM PDT

Ancient Psychoactive Plant Used in the Iron Ages

WRITTEN BY: Greta Anne

The recent discovery of Peganum harmala (Syrian rue) residues in Iron Age fumigation devices from the archaeological site of Qurayyah in Saudi Arabia offers a groundbreaking glimpse into ancient medicinal and ritualistic practices in northwest Arabia. An article published in Nature explores the findings; this marks the earliest material evidence for the use of P. harmala in burned form, confirming longstanding oral and ethnobotanical traditions.

P. harmala has a long-standing reputation across West Asia and North Africa for its potent bioactive properties. Traditionally, it has been consumed in various ways—ingested as a tea, applied topically, or inhaled via smoke from burning seeds and roots. The Qurayyah discovery underscores the use of this plant in fumigation, setting it apart from ingestion-based applications and aligning it with household-level medicinal or protective rituals. Notably, the residues were exclusively found in residential areas, suggesting a domestic context rather than ceremonial or funerary functions.

The therapeutic value of P. harmala is deeply rooted in regional medical systems. Its seeds possess analgesic, anti-inflammatory, antispasmodic, and even mood-stabilizing effects, making them valuable in managing ailments like toothaches, headaches, joint pain, and menstrual irregularities. While many of these treatments were traditionally administered through ingestion or topical application, the Qurayyah evidence suggests that inhalation through fumigation was also a significant therapeutic route, particularly for ailments involving pain relief or psychological discomfort.

The plant’s fumigant properties extend to hygiene and sanitation. P. harmala smoke is known to possess antibacterial and antifungal properties, making it an effective disinfectant for household environments. In arid, close-knit oasis communities such as Qurayyah, this would have been crucial for maintaining public health. The pungent nature of its smoke makes it unlikely that it was used for fragrance or aesthetic olfactory purposes. Instead, its use likely reflects a practical approach to pest control and air purification—highlighting a nuanced understanding of natural pharmacology in ancient Arabian households.

“This discovery shows the deep historical roots of traditional healing and fumigation practices in Arabia, we’re preserving not only objects, but the intangible cultural heritage of ancient knowledge that still holds relevance in local communities today,” says Ahmed M. Abualhassan, Heritage Commission co-director of the Qurayyah project.” In a global landscape increasingly seeking sustainable and natural health solutions, such rediscoveries are not only academically enriching but potentially instructive for modern medicine.  

Sources: Nature, EurekAlert

About the Author
Doctor of Pharmacy (PharmD)
Greta holds her PharmD and is a writer at Labroots. She also has a strong background in neuroscience & psychology. When she is not working as a pharmacist or a writer, she enjoys fostering her creative initiatives such as traveling, working out, spending time at the beach, and cooking!
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