A Practical Guide to Hot-Melt Extrusion for Enhanced Drug Delivery

Preparation of an Amorphous Solid Dispersion by Hot-Melt Extrusion

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Developing oral solid dosage forms often comes with a critical challenge: improving the solubility and bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Nearly 90% of new molecules suffer from low solubility, limiting their absorption and therapeutic potential. Hot-melt extrusion (HME) has become a proven technology to overcome these barriers, enhancing drug delivery, enabling modified release, and supporting patient compliance.

In this free eBook, you’ll gain a clear understanding of how hot-melt extrusion is applied in the preparation of amorphous solid dispersions, and why it is now a cornerstone in modern pharmaceutical formulation development.

In this eBook you will find:

• Improving Bioavailability: How HME enhances solubility and absorption of poorly soluble APIs.
• Flexible Dosage Forms: Tablets, capsules, implants, and more from extruded drug-polymer matrices.
• Scalable Manufacturing: Why twin-screw extrusion is the gold standard for continuous, solvent-free production.