DNA Synthesis for mRNA Therapeutics - How to Ensure Good Results by Choosing the Right DNA

Over the last two decades, DNA synthesis has established itself as a standard tool propelling life science research in a wide range of fields. In this session, we will highlight how DNA synthesis tools can support mRNA therapeutics development.

One key benefit of synthetic DNA is that it enables flexible sequence design independent of any naturally occurring template. Methods for optimization of expression in a target organism will be discussed, focusing on how to achieve best results in mammalian systems. The ability to design sequences also enables incorporation of additional layers of information into the DNA. To this end, a method for “molecular watermarking” will be described, which can enable tracking and tracing of a molecule throughout the application.

Learning objectives:

1. Demonstrate understanding of the benefits of synthetic DNA, including flexible sequence design and incorporation of additional layers of information.

2. Discover methods for optimizing expression in target organisms, particularly in mammalian systems.

3. Develop insight on the various applications of mRNA therapeutics and how synthetic biology technologies can support their development and commercialization.