Genetically-Engineered Immuno-oncology Cell Lines and Services for Early Drug Discovery Research and Preclinical Manufacturing

Gene editing experts within MilliporeSigma’s Cell Design Studio™ provide premier custom cell line engineering services to create and deliver unique cell-based assays tailored for drug discovery and preclinical manufacturing. Our cellular models have been used for applications such evaluating efficacy of CAR-T cells, screening candidate checkpoint inhibitors, and generating potency assays for therapeutic testing. We have also generated new functional biologically-relevant tumor-associated antigen and monoallelic HLA panel cell lines that express either individual tumor antigens at varying levels or individual HLAs. In this presentation, we will discuss the technology of these lines, their utility in immuno-oncology and novel therapeutic testing, and how they can fit in your workflow.

Learning Objectives:

1. Understand the limitations of cells commonly used in immuno-oncology assays

2. Learn about engineered tumor-associated antigen cell panels

3. Gain insight into the benefits of mono-allelic HLA expressing cell lines