The flexibility of the BioMark Real-Time PCR System, allow us to preform genetic research using different types of nano-fluidic (48.48 or 96.96) chips setup, in the thermal cycle of these chips and image the data in real time for quantity determination of DNA copy numbers (CNV) or mRNA expression in multiple loci locations or genes, and can also to be used as an endpoint image reader for analyzing different allelic genotyping frequencies like in a panel of 92 most common mutations, in the Israeli populations, for 42 different mono genetic disorders, and 15-14 common mutations in Breast/Ovarian and Colon cancers.
Digital-PCR gene chip were used to determine the number of a human gene which were incorporated in a plant cells for the production of this protein to treat human disease. CGH array and next-generation sequencing (NGS) technologies has reduced sequencing cost by orders of magnitude and significantly increased the throughput, making whole-exom sequencing a possible way for obtaining global genomic information about patients on whom clinical actions may be taken and were used to locate new genes associated with complex clinical genetic diseases. Tumors genetic is define using OnocoScan gene chip and the nano-fluidic gene chips by RT-PCR reactions on several most common somatic mutations to define most suitable chemotherapy treatments in different cancers types.