Unraveling the Roles of Copy Number Variants in Tumorigenesis

Genomic analysis of cancer cells revealed comprehensive mechanism of tumorigenesis in human patients. Among the abnormalities discovered so far, CNVs accounted for a great portion of all the frequently observed pathogenic variants, and serve as important biomarkers for early-detection, diagnosis, prognosis and follow-up patient care. OncoScan CNV assays, as one of the most common CNV analysis tool for solid tumor samples, displayed robust ability in detecting gain, loss and LOH that play an essential role in cancer origination, progression and metastasis. It has the advantage of processing highly degraded and/or low quality samples, which is frequently observed in solid tumor samples. In this talk, we will focus on its development history and current application in research setting to decipher the molecular and cytogenetic mechanisms in a few representative types of solid tumors.
 
Learning Objectives:
 
The audience will go through the history/development of cytogenetics/cytogenomics
The audience will get familiar with current cytogenetic analysis tools
The audience will understand the advantages of OncoScan compared to other array/NGS platforms
The audience will know what types of tumor samples OncoScan could be used for analysis