In this presentation I will describe results from a family study designed to identify the genetic cause for familial clustering of several early onset cancers.   Data from next generation sequencing combined with expression studies were integrated along with the familial cooccurrence of cancers to identify a genomic region of interest and then to further identify a genetic factor influencing cancer risk.  This factor also interacted with a second factor.  The presentation describes integration of family studies, genomic analysis and expression studies for gene discovery and characterization.