VITROS® Microslides utilize a layered, dry-slide technology that enables separate reaction domains such that each step can be optimized to provide excellent assay performance. Excellent precision and accuracy are achieved through designs that combine multiple discrete layers of spreading, masking, scavenger, and other reagent layers. Dry-slide methods use traditional, well-accepted analytical principals and are traceable to accepted reference methods, so that results are consistent over time and around the world. This presentation will focus on three differentiating features of VITROS® Microslide technology: 1) minimization of paraprotein interference in chemistry assays, 2) direct potentiometric measurement of sodium utilizing a disposable ion selective electrode (ISE), and 3) direct measurement of unconjugated, conjugated, and total bilirubin utilizing reflectance spectrophotometry. All three of these features have been demonstrated to improve the clinical/analytical accuracy of assay results.