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Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that i...
Genomic research has long been skewed toward European populations, leading to significant underrepresentation of Non-European groups in both research studies and genomic databases. This bias...
Cancer neoantigens arise from protein-altering somatic mutations in tumor and rank among the most promising next-generation immuno-oncology agents when used in combination with immune checkp...
To determine efficacy of specific complementary therapies to advance evidence-based, integrative healthcare, the complementary modality should first be introduced to stakeholders to determin...
Immunotherapy has changed the landscape of oncology, improving survival rates for many patients across a variety of malignancies. Two antibody-based immunotherapies, immune checkpoint inhibi...
There are known health outcome disparities among those with pancreatic neuroendocrine tumors (pNET) of minority race and those living with adverse social determinants of health (SDOH) (rural...
Fluorescence microscopy offers robust, multi-parametric and scalable analysis of cell level activity in heterogenous populations with spatial and temporal resolution, often critical for effe...
The cellular physiology of microbes can vary significantly within a population, even when exposed to identical external conditions. Recent theoretical and experimental studies have shown tha...
Heart failure, in the simplest of terms, indicates that a problem with the ventricles is preventing the heart from filling and/or pumping correctly. It is the result of a complex mechanical...
This webinar is designed to explore the fundamental characteristics of reverse transcriptases and the essential factors that play a pivotal role in achieving high-quality cDNA synthesis from...
The quest to decipher the complex molecular events underpinning cell polarity and organelle segregation during eukaryotic cell division presents a formidable challenge. A predominant focus o...
The disposition of antibody-based therapeutics is generally determined by both target-mediated and non-target processes, the latter being an often-overlooked aspect. Target-independent liabi...
abstract Learning Objectives Understand how the health disparity affects ordering M-protein testing at the right time. Discuss Analytical considerations of the test panel/methods ordered Ide...
A unique opportunity to deepen understanding of how labs can contribute to antibiotic stewardship efforts by running efficient Procalcitonin testing, yielding significant impacts on patient...
A microphysiological system is a 3D in vitro model that mimics human tissue environments with high physiological relevance. This approach enhances our understanding of disease mechanisms, dr...
Numerous biomedical applications have been described for liver-humanized mouse models, such as in drug metabolism or drug-drug interaction (DDI) studies. However, the strong enlargement of t...
Organisms sense and respond to changes in the environment through signal transduction pathways. Pathways like highly conserved Mitogen-Activated Protein Kinase (MAPK) pathways are composed o...
One of the primary limitations in drug discovery and toxicology research is the lack of good model systems between the single cell level and animal or human systems. This is especially true...
Super-resolution microscopy, or nanoscopy, enables the use of fluorescent-based molecular localization tools to study molecular structure at the nanoscale level in the intact cell. Analysis...
The field of carrier screening has rapidly developed over the past several years, in terms of technology, guidelines for testing, and patient knowledge. This webinar aims to educate the audi...
In quantitative polymerase chain reaction (qPCR), multiplexing increases sample throughout, while reducing the time and cost associated with having separate reactions for each target. Furthe...
The effect of long-term mixed-waste contamination, particularly uranium and nitrate, on the microbial community in the terrestrial subsurface at the Oak Ridge Integrated Field Research Chall...
The effects of spaceflight on those beneficial microbes that associate with animal tissues is an emerging area in space biology, however, many questions persist regarding how homeostasis bet...
Trauma such as burn continues to be a major cause of morbidity and mortality in the United States. Gut barrier dysfunction is often implicated in post trauma complications. Intoxication at t...
Respiratory tract infections (RTIs) are a significant public health concern due to their widespread transmission and high rates of illness and death globally. Syndromic molecular methods hav...
In recent past respiratory seasons, the world witnessed a “tripledemic” of Influenza (flu), SARS-CoV-2 (COVID-19), and Respiratory Syncytial Virus (RSV). In this presentation, I...
Bacterial vaginosis is a common cause of vaginal complaints, mainly of odor and discharge in women of reproductive age. BV is poorly understood and recurrence is frequent. More questions tha...
Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that i...
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