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Speech neuroprostheses have the potential to restore communication to people living with paralysis, but naturalistic speed and expressivity are elusive. Here we use high-density surface reco...
This talk will present the methodology of using the guided ultrasonic waves generated by the rodent to track its physiology, behavior, and psychological state. When behaving in an environmen...
Behaving animals continually reconcile the internal states of their neural circuits brain-wide with incoming sensory and environmental evidence to evaluate when and how to act. The brains of...
To make movement and foraging decisions in a naturalistic environment, multiple neural populations must work synergistically to produce successful actions. These decisions span multiple scal...
Virginia will discuss work on single-trial analysis of EEG signals during episodic memory tasks. They develop single-trial classifiers to predict whether people will remember pictures from E...
Individuals with substance use disorders often show impaired sensitivity to reward value. However, it is not clear whether such impairment impacts reward-related decision making and whether...
Studying motor behaviors can reveal fundamental principles of the brain and mind. This presentation focuses on our work towards developing the hardware and computational tools that will allo...
With the internet, society has been exposed to puzzling and exquisite animal behavior, while neuroscience has vastly concentrated on a few inbred animal models studied in trained unnatural s...
A core goal of neuroscience is to understand how the brain adaptively orchestrates movements to execute complex behaviors. Quantifying behavioral dynamics, however, has historically been pro...
How do the cognitive and physiological traits of individuals translate into real-world group dynamics? There is an empirical and theoretical gap between understanding individual-level proces...
Our ability to record large-scale neural and behavioral data has substantially improved in the last decade. However, the inference of quantitative dynamical models for cognition and motor co...
Social animals congregate in groups and communicate with vocalizations. To study the dynamics of natural vocal communication and their neural basis, one must characterize signals used for co...
Transdisciplinary knowledge producing teams (TDKPTs) dedicate their efforts to solving wicked problems. Successful TDKPTs embody characteristics of complex adaptive systems (CAS) and exempli...
Many behaviors are learned through trial and error by matching performance to internal goals, yet neural mechanisms of performance evaluation remain poorly understood. We recorded basal gang...
Mental health is a multidimensional challenge, marked by rapid brain changes and essential interpersonal relationships. This complicates the application of traditional statistical methods an...
The ultimate goal of neuroscience is to understand and explain real-world behavior in terms of brain activity, and to use these insights to develop therapeutic approaches for neural disorder...
Vestibular sensation anchors our perception of the environment and is crucial for maintaining balance during locomotion. Vertebrate animals use the evolutionarily conserved vestibular system...
In recent years, small volume biopsies have been increasingly utilized for diagnosis of tumors in both primary and recurrent settings. Concomitantly, the numbers of ancillary studies for cha...
mRNA‑based products are rapidly growing in the biotherapeutics space. Important considerations need to be made to develop a process for mRNA synthesis that consistently generates high‑yield...
Interoceptive signals dynamically interact with the environment to shape appropriate defensive behaviors. Neurons in the hypothalamus regulate internal states, such as thirst and circadian r...
This presentation explores the pharmacokinetics (PK) and pharmacodynamics (PD) of β-lactam antibiotic dosing, particularly in ICU patients. To optimize PK/PD targets, two strategies are...
Multiplex immunofluorescence is a powerful tool for phenotyping cells from a single tissue slide, while preserving spatial context. The MultiOmyxTM platform, offered as an end to end service...
The study of a single cell, the fundamental unit of our complex bodies, has become an important field in cellular biology, and researchers are using single-cell analysis to shed new light on...
NAFLD (non-alcoholic fatty liver disease) is a global epidemic that affects 25% of the world’s population, with its epicentre in the West. Twenty percent of NAFLD patients go on to dev...
Learning Objectives: 1. Summarize the benefits and challenges of current preclinical methods in drug discovery and development. 2. Review new alternative methodologies (NAMs) and microphysio...
Proliferation biomarkers are proteins that are up-regulated in growing cells. Immunological staining of tumor tissue can provide an indication of the aggressivity of the tumor and provide in...
Globally there has been a constant rise in the population suffering from cardiovascular diseases mostly due to metabolic complications. We have made use of two high throughput omics-based ap...
Speech neuroprostheses have the potential to restore communication to people living with paralysis, but naturalistic speed and expressivity are elusive. Here we use high-density surface reco...
