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Across oncology applications, from research to molecular testing and pharmaceutical development, the ability to identify potentially actionable genetic alterations and exploit the molecular...
As the SARS-CoV-2 continues to spread and evolve and vaccination efforts are under way, countries around the world are confronting new public health challenges due to the emergence and rapid...
Room air conditions are hypothermic, hypocapnic and hyperphysioxic from the cells’ point of view. Yet we stress cells with these uncontrolled conditions routinely. It is no wonder that...
Background and aim: Worldwide malaria cases have declined. However, despite recent advances, resistance to front line drugs and insecticides means the burden remains high (219 million cases...
NGS Bioinformatics software has come of age. Our workflows need software solutions that don’t only carry out the correct calculations to give the correct results reliably and unambiguo...
B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
Antibody–drug conjugates (ADC) are targeted therapies that are designed to deliver highly potent cytotoxic agents to specific tumor cells saving normal tissue. They combined a monoclon...
This presentation will cover the purpose of the Annex 1 update, scope, principles, regulatory expectations, what's next and solutions to help ensure readiness....
LRRK2 is a large (2,527 amino acids) multi-domain protein consisting of 7 putative domains, including a Ras-like GTPase domain called ‘Ras of complex proteins’ (Roc) followed by a...
The central nervous system (CNS) is a conglomerate of diverse, interconnected tissues that each contain cell phenotypes specific to their distinct anatomical region. Recent studies have demon...
In the last two decades, large amount of next-generation sequencing (NGS) and -omics data has been generated in the field of immuno-oncology. Generating hypotheses by analyzing hundreds if no...
Graphene-based Biology-gated Transistors (Cardean Transistors) directly read molecular signals of active biology using advanced electronics. This proprietary tech breakthrough can be used as...
As a response to various inflammatory stimuli, neutrophils and macrophages expel a mixture of their nuclear and granular elements in the form of extracellular traps (ETs). These web-like sub...
Image analysis in a real-world situation rarely involves solving a single unchanging problem. Modern tools need to be flexible and adaptable not only to solve todays problems but to support...
Recent clinical successes in cancer genome-inspired personalized medicine have been a major breakthrough in drug discovery. However, 98% of the patients have an incomplete therapeutic respons...
Mammalian mucosal niches are colonized by a complex ecosystem of viruses, bacteria and fungi termed the microbiome. Unlike the gut microbiome, the vaginal microbiome is composed of small num...
The assessment of pigmented lesions is a difficult area of dermatology and dermatopathology. Melanoma is the leading cause of cancer in woman age 25-29 years, yet it is also a leading c...
The OrganoPlate is a microtiterplate based Organ-on-a-Chip platform for high throughput drug safety and efficacy screening. It contains up to 96 cell culture chambers that allow co-culture o...
Antimicrobial resistance is an important and pressing challenge for global human health. Several obstacles in understanding, diagnosing, and treating antimicrobial resistance limit our abili...
The evolution of clinical trial design in oncology reflects the current clinical paradigm of personalized medicine, weighing both histology and molecularly-defined biomarkers as the pillars...
Early adverse exposures, such as maternal stress during pregnancy and child abuse, are thought to result in long-lasting consequences on neural circuit function and stress hormone regulation...
Recent advances in high-throughput single-cell transcriptomics and epigenomics methods allow to measure the expression of thousands of genes and identify the gene transcriptional regulation...
The Type 2 Diabetes Knowledge Portal is an open-access resource for human genetic information on type 2 diabetes (T2D). It is a central repository for data from large genomic studies that ide...
Diabetes is a debilitating chronic disease that is spirally out of control. Fundamentally, the progressive failure of pancreatic beta cells results in decreased insulin secretion, ultimately ...
Across oncology applications, from research to molecular testing and pharmaceutical development, the ability to identify potentially actionable genetic alterations and exploit the molecular...
